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为探讨牛磺酸防治肠源性内毒素血症的可能性，本文在大鼠离体回肠灌流模型上观察了牛磺酸对内毒素血症和内皮素灌流促进肠道内毒素转移的影响。结果显示，内毒素和内皮素明显促进肠腔内毒素向血循环转移（与对照组相比分别增加８５％和１８７％，（Ｐ＜０．０１）。循环灌流液中加入１０ｍｍｏｌ／Ｌ的牛磺酸可明显抑制内毒素和内皮素引起的肠道内毒素转移（转移率分别降低５９％和６５％，（Ｐ＜０．０１）并抑制内皮素引起的肠道粘膜组织乳酸脱氢酶释放。本文提示，牛磺酸可能通过其细胞保护机制抑制肠道内毒素转移，对防治肠源性内毒素血症有潜在的临床应用前景。Ｐ＜０．０１．（４）组与（２）组相比，（６）组与（５）组相比，＋Ｐ＜０．０５；＋＋Ｐ＜０．０１３讨论肠道内毒素转移进而导致＂肠源性内毒素血症＂①，常发生在各种严重疾病情况下（如休克、烧伤、创伤等），并可引起多器管功能衰竭②③。肠道内毒素转移的机制尚不清楚，通常认为与肠粘膜屏障功能和肝脏解毒能力降低有关⑥⑦，我们以前在整体动物进行的研究发现，某些循环因子（如循环内毒素、内皮素等）可促进肠腔内毒素转移，是肠源性内毒素血症的重要发病因素⑧⑨。本文在离体回肠灌流模型上也得到类似结果。肠循环灌流牛磺酸（?
In order to explore the possibility of taurine in preventing intestinal endotoxemia, the effect of taurine on endotoxemia and endotoxin perfusion to promote intestinal endotoxin transfer in rats was studied in vitro. The results showed that endotoxin and endothelin obviously promoted the transfer of intestine endotoxin to the blood circulation (increased by 85% and 187% respectively compared with the control group (P <0.01) .In addition, 10mmol / L taurine Acid significantly inhibited endotoxin and endothelin-induced intestinal toxin transfer (metastasis rate decreased by 59% and 65%, respectively (P <0.01) and inhibited endothelin-induced intestinal mucosal lactate dehydrogenase release. These results suggest that taurine may inhibit the toxin transfer through the cytoprotection mechanism and has potential clinical application in the prevention and treatment of enterogenous endotoxemia.P <0.01. (4) Compared with group (2) , (6) + P <0.05 compared with group (5); ++ P <0.013 Discussion of intestinal endotoxin transfer leading to “enterogenous endotoxemia” ① often occurs in various serious diseases (Such as shock, burns, trauma, etc.), and can lead to multiple tube failure ② ③. The mechanism of intestinal endotoxin transfer is not clear, it is generally believed that with the intestinal mucosal screen Function and liver detoxification ability ⑥ ⑦, our previous studies conducted in the whole animal found that certain circulating factors (such as circulating endotoxin, endothelin, etc.) can promote intestinal endotoxin transfer is intestinal endotoxemia Important risk factors ⑧ ⑨ This article also obtained similar results in isolated ileal perfusion model intestinal perfused taurine (?