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严重的再生障碍性贫血(再障)是肝炎的一个罕见的并发症。这些病例引起肝炎的致病因子未曾作鉴定。作者研究一组与肝炎相关的再障患者,寻找新近的甲型和乙型肝炎病毒感染的证据。 149例严重再障中20例(13.4％)再障与肝炎相关(均于再障发生前不到8个月曾临床诊断为肝炎,且均无接触巳知的肝或骨髓毒素史)。20例中19例于临床肝炎发生期间血清HBsAg阴性。20例均否认于肝炎发生前输注过血液制品或用血污染的器械作过接种。20例中16例的血清标本可供详细分析。16例均为男性,平均年龄19.3±9.0岁(3～40岁)。1例有肝病史。从肝炎发病到再障的平均间隔时间为11.9±9.9周(0～32周)。骨髓衰竭发生时,12例丙氨
Severe aplastic anemia (aplastic anemia) is a rare complication of hepatitis. These cases caused by hepatitis virulence factors have not been identified. The authors looked at a group of hepatitis-related aplastic anemia patients looking for evidence of recent hepatitis A and B virus infections. Of the 149 patients with severe aplastic anemia, 20 (13.4%) had aplastic anemia associated with hepatitis (all were clinically diagnosed as hepatitis less than 8 months before the onset of aplastic anemia and had no history of exposure to known liver or myelotoxin). Nineteen of the 20 patients were negative for HBsAg during clinical hepatitis. Twenty patients all denied that they had been infused with blood products or contaminated with blood before the onset of hepatitis. 16 cases of 20 cases of serum samples for detailed analysis. All 16 patients were male, with an average age of 19.3 ± 9.0 years (range 3 to 40 years). One case had a history of liver disease. The mean interval from onset of hepatitis to aplastic anemia was 11.9 ± 9.9 weeks (0-32 weeks). Bone marrow failure occurs when 12 cases of ammonia