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目的:研究Caprini风险评估模型联合D-二聚体对子宫切除术围手术期静脉血栓栓塞性疾病（VTE）的诊断价值。方法:回顾性分析广东省廉江市妇幼保健院2017年2月至2019年2月160例行子宫切除术患者的临床资料。其中，围手术发生VTE 80例（VTE组），未发生VTE 80例（对照组）。分析比较Caprini风险评估模型、D-二聚体和Caprini风险评估模型联合D-二聚体诊断VTE的敏感度、特异度、阳性预测值、阴性预测值、阳性似然比、阴性似然比和约登指数，并采用受试者工作特征（ROC）曲线评估诊断效能。结果:VTE组Caprini风险评估模型和D-二聚体阳性率均明显高于对照组［87.50%（70/80）比17.50%（14/80）和90.00%（72/80）比41.25%（33/80）］，差异有统计学意义（n P<0.05）。Caprini风险评估模型评估子宫切除术患者围手术期发生VTE的敏感度为87.50%（70/80），特异度为82.50%（66/80），阴性预测值为86.84%（66/76），阳性预测值为83.33%（70/84），阴性似然比为0.15，阳性似然比为0.50，约登指数为0.70；D-二聚体评估子宫切除术患者围手术期发生VTE的敏感度为90.00%（72/80），特异度为58.75%（47/80），阴性预测值为85.45%（47/55），阳性预测值为68.57%（72/105），阴性似然比为0.17，阳性似然比为2.18，约登指数为0.49；Caprini风险评估模型联合D-二聚体评估子宫切除术患者围手术期发生VTE的敏感度为97.50%（78/80），特异度为52.50%（42/80），阴性预测值为95.45%（42/44），阳性预测值为67.24%（78/116），阴性似然比为0.05，阳性似然比为2.05，约登指数为0.50。Caprini风险评估模型、D-二聚体和Caprini风险评估模型联合D-二聚体诊断子宫切除术患者围手术期发生VTE的曲线下面积分别为0.888、0.877和0.945（95%n CI 0.833 ~ 0.943、0.820 ~ 0.933和0.908 ~ 0.983，n P<0.01）。n 结论:Caprini风险评估模型和D-二聚体在诊断子宫切除术围手术期发生VTE均有良好的效果，Caprini风险评估模型联合D-二聚体诊断价值最高。“,”Objective:To evaluate the diagnostic value of the Caprini risk assessment model combined with D-dimer in perioperative venous thromboembolic (VTE) of hysterectomy.Methods:The clinical data of 160 patients who had underwent hysterectomy in Lianjiang City Maternal and Child Health Hospital from February 2017 to February 2019 were retrospectively analyzed. During perioperative period, VTE occurred in 80 patients (VTE group), and 80 patients had no VTE (control group). The sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio and Youden index of Caprini risk assessment model, D-dimer level detection and Caprini risk assessment model combined with D-dimer in the diagnosis of VTE were analyzed and compared, and the diagnostic efficacy was evaluated by receiver operating characteristic (ROC) curve.Results:The positive rates of Caprini risk assessment model and D-dimer in VTE group were significantly higher than those in control group: 87.50% (70/80) vs. 17.50% (14/80) and 90.00% (72/80) vs. 41.25% (33/80), and there was statistical difference (n P<0.05). The sensitivity, specificity, negative predictive value, positive predictive value, negative likelihood ratio, positive likelihood ratio and Youden index of the Caprini risk assessment model were 87.50% (70/80), 82.50% (66/80), 86.84% (66/76), 83.33% (70/84), 0.15, 0.50 and 0.70, respectively; the indexes of D-dimer were 90.00% (72/80), 58.75% (47/80), 85.45% (47/55), 68.57% (72/105), 0.17, 2.18 and 0.49, respectively; the indexes of Caprini risk assessment model combined with D-dimer were 97.50% (78/80), 52.50% (42/80), 95.45% (42/44), 67.24% (78/116), 0.05, 2.05 and 0.50, respectively. The areas under curve of Caprini risk assessment model, D-dimer and Caprini risk assessment model combined with D-dimer were 0.888, 0.877 and 0.945 (95%n CI 0.833 to 0.943, 0.820 to 0.933 and 0.908 to 0.983, n P < 0.01).n Conclusions:Caprini risk assessment model and D-dimer have good results in the diagnosis of perioperative VTE of hysterectomy, and Caprini risk assessment model combined with D-dimer has the highest diagnostic value.