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目的:研究银杏叶提取物治疗肺间质纤维化的临床效果。方法:选取该院在2012年6月至2014年6月收治的135例肺间质纤维化患者作为研究对象,随机将患者分为两组,分别为实验组与对照组,其中实验组68例患者,对照组67例患者。对照组患者采用强的松进行治疗,1次/d30mg强的松口服;实验组患者采用银杏叶提取物进行治疗,3次/d,1 g/次口服。两组分别进行为期3个月的治疗,治疗期间避免使用免疫抑制剂类药物,疗程结束后,对比两组患者的临床症状,包括患者的肺功能、动脉氧分压、CT以及肿瘤坏死因子的变化情况。结果:两组患者的动脉氧分压、肺弥散功能、肺活量以及肺总量与治疗前相比,有了明显的改善(P<0.05),但两组患者的差异没有统计学意义(P>0.05)。结论:银杏叶提取物治疗肺间质纤维化效果明显,适合推广应用。
Objective: To study the clinical effect of Ginkgo biloba extract on pulmonary interstitial fibrosis. Methods: A total of 135 patients with pulmonary interstitial fibrosis who were admitted to our hospital from June 2012 to June 2014 were selected as the study subjects. The patients were randomly divided into two groups: experimental group and control group, in which 68 cases Patients, control group of 67 patients. Control group patients were treated with prednisone, 1 / d 30mg prednisone oral; experimental group of patients treated with ginkgo biloba extract, 3 times / d, 1 g / orally. The two groups were treated for 3 months respectively. During the treatment period, immunosuppressants were avoided. After the treatment, the clinical symptoms of the two groups were compared, including pulmonary function, arterial oxygen tension, CT and tumor necrosis factor Changes. Results: The arterial oxygen pressure, pulmonary diffusing capacity, vital capacity and total lung volume were significantly improved in both groups (P <0.05), but there was no significant difference between the two groups (P> 0.05). Conclusion: Ginkgo biloba extract for pulmonary interstitial fibrosis obvious effect, suitable for the promotion and application.