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CeCl_3·7H_2O supported on silica(CeCl_3·7H_2O-SiO_2) is used as a heterogeneous,efficient and recyclable catalyst for a three component one-pot reaction of an amine,aldehydes and diethyl phosphite to synthesizeα-diaminophosphonate derivatives under microwave irradiation exploiting neat reaction conditions.Tenα-diaminophosphonates(6a-j) of 4,4’-sulfonyldianiline(Dapsone)(3) were synthesized and structural elucidation was confirmed by spectral data.Antifungal and antioxidant activities were evaluated include minimum inhibitory concentrations and IC_(50) values,respectively of the titled compounds.Compounds 6h,6i exhibited promising antioxidant activity at lower IC_(50) values 53.7μg/mL, 53.2μg/mL,respectively as compared with standard IC_(50) value 51.6μg/mL.
CeCl_3 · 7H_2O-SiO_2 is used as a heterogeneous, efficient and recyclable catalyst for a three component one-pot reaction of an amine, aldehydes and diethyl phosphite to synthesize α-diaminophosphonate derivatives under microwave irradiation exploiting neat reaction (6a-j) of 4,4’-sulfonyldianiline (Dapsone) (3) were synthesized and structural elucidated was confirmed by spectral data. Antifungal and antioxidant activities were evaluated include minimum inhibitory concentrations and IC_ (50) values , respectively of the titled compounds. Compounds 6h, 6i exhibited improved antioxidant activity at lower IC 50 values 53.7 μg / mL, 53.2 μg / mL, respectively as compared with standard IC 50 values 51.6 μg / mL.