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目的：研究不同浓度赶黄草对酒精肝小鼠谷丙转氨酶，尿酸及肌酐的影响。方法成年健康小鼠50只，按体重随机分为5组，每组10只，分别为酒精模型组，低浓度药物治疗组，中浓度药物治疗组，高浓度药物治疗组，正常对照组。前四组每天给予5ml/kg，浓度50%的乙醇灌胃，连续30d，同时药物影响的三组给予不同浓度的药物治疗，正常对照组灌相同量的蒸馏水。实验结束，取动物肝脏进行病理组织学检查，血清进行生化检测。结果对小鼠肝组织内谷丙转氨酶，尿酸及总胆固醇含量的影响与正常对照组比较，赶黄草小鼠肝组织内的 GPT，UA 含量显著下降，差异有统计学意义（P<0.05）。提示高剂量的赶黄草对小鼠长期过量饮酒肝损伤有明显的保护作用。“,”PurPose: To study that different concentration of Penthorum chinese Pursh have significant Protected effects on the liver damage of long time excessive alcohol consumPtion. Methods: According to their body weights, adult healthy mice were randomly divided into 5 grouPs with each 10 mice: alcohol model grouP, low concentration medicine treatment grouP, middle concentration medicine treatment grouP, high concentration medicine treatment grouP and normal control grouP. The Previous four grouPs received 5ml/kg, 50% alcohol for 30 consecutive days, at the same time, the three medicine treatment grouP received different intensity drugs theraPy, normal control grouP received the same amount of distilled water. After the exPeriment, the GPT and UA level significantly decreased in the liver of the exPeriment mice received Penthorum chinese Pursh and the differences were statically significant (P<0.01). The result shows that high concentration of Penthorum chinese Pursh have significant Protected imPacts on the liver damage of long time excessive alcohol consumPtion.