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目的观察噻托溴铵治疗稳定期老年慢性阻塞性肺病(COPD)的临床疗效。方法选取60例稳定期老年COPD患者作为研究对象,随机分为研究组与对照组,每组30例。研究组患者给予噻托溴铵治疗,对照组给予异丙托溴铵治疗,比较两组治疗效果、肺功能指标及不良反应情况。结果研究组治疗总有效率(93.3%)高于对照组(67.5%),差异有统计学意义(P<0.05);治疗后研究组FEV1/FVC、FEV1等肺功能指标改善效果均优于对照组,差异有统计学意义(P均<0.05);两组药物治疗过程中均有2例出现口干,病症较轻未给予处理,自行缓解。结论噻托溴治疗稳定期老年COPD临床疗效显著,且无严重不良反应。
Objective To observe the clinical efficacy of tiotropium in the treatment of elderly patients with chronic obstructive pulmonary disease (COPD). Methods Sixty elderly stable COPD patients were selected as study subjects and randomly divided into study group and control group with 30 cases in each group. Patients in the study group were treated with tiotropium, while those in the control group were treated with ipratropium bromide. The therapeutic effects, lung function indexes and adverse reactions of the two groups were compared. Results The total effective rate (93.3%) in the study group was higher than that in the control group (67.5%), the difference was statistically significant (P <0.05). After treatment, FEV1 / FVC and FEV1 improved the pulmonary function indexes better than the control Group, the difference was statistically significant (P all <0.05); two groups of patients in the course of drug treatment, there are two cases of dry mouth, mild illness did not give treatment, relieve themselves. Conclusion The efficacy of tiotropium in the treatment of stable COPD in elderly patients is significant and has no serious adverse reactions.