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目的探讨白细胞介素(IL)-18在支气管哮喘发病机制中的作用。方法收集30例哮喘患者和15名健康对照者的血浆,采用酶联免疫吸附试验(ELISA)检测血浆中IL-18、IL-12和IL-13的水平。结果哮喘组血浆IL-18、IL-13水平明显高于对照组,IL-12水平则显著低于对照组,差异有显著性(P<0.01)。哮喘组IL-18和IL-13呈显著正相关(P<0.05)。结论IL-18可能参与了哮喘的发病过程,它通过调节Th1/Th2的活性及细胞因子的产生,在哮喘的发病过程中发挥作用。
Objective To investigate the role of interleukin (IL) -18 in the pathogenesis of bronchial asthma. Methods The plasma of 30 asthmatic patients and 15 healthy controls were collected. The levels of IL-18, IL-12 and IL-13 in plasma were detected by enzyme linked immunosorbent assay (ELISA). Results The levels of plasma IL-18 and IL-13 in asthma group were significantly higher than those in control group, while the levels of IL-12 in asthma group were significantly lower than those in control group (P <0.01). There was a significant positive correlation between IL-18 and IL-13 in asthma group (P <0.05). Conclusion IL-18 may be involved in the pathogenesis of asthma. It plays a role in the pathogenesis of asthma by regulating the activity of Th1 / Th2 and the production of cytokines.