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目的观察奥美拉唑序贯疗法治疗消化性溃疡的临床效果。方法选择2011年1月—2014年12月内镜检查诊断为胃溃疡或十二指肠溃疡并经14C尿素呼吸试验确证为HP阳性的门诊或住院患者164例,随机分为观察组和对照组各82例。观察组服用奥美拉唑+左氧氟沙星+阿莫西林治疗14 d,14 d后单用奥美拉唑序贯治疗4周。对照组服用奥美拉唑+左氧氟沙星+阿莫西林治疗14 d。比较两组患者临床疗效、HP根除率和不良反应。计数资料采用χ2检验,P<0.05为差异有统计学意义。结果观察组总有效率为95.12%,对照组为84.15%,两组比较差异有统计学意义(χ2=5.316,P<0.05)。观察组HP根除率为91.46%,对照组为80.49%,两组比较差异有统计学意义(χ2=4.096,P<0.05)。观察组和对照组不良反应率分别为7.32%和6.10%,两组比较差异无统计学意义(χ2=0.097,P>0.05)。结论奥美拉唑序贯疗法治疗HP阳性消化性溃疡临床疗效确切,HP根除率高,患者服药依从性高,值得基层医院推广应用。
Objective To observe the clinical effect of sequential therapy of omeprazole in the treatment of peptic ulcer. Methods One hundred and sixty-four outpatients or inpatients with endoscopic diagnosis of gastric ulcer or duodenal ulcer endoscopically diagnosed as HP-positive by 14C urea breath test from January 2011 to December 2014 were randomly divided into observation group and control group Each of 82 cases. The observation group was treated with omeprazole + levofloxacin + amoxicillin for 14 days, followed by omeprazole for 14 weeks after 14 days. The control group took omeprazole + levofloxacin + amoxicillin for 14 days. Clinical efficacy, HP eradication rate and adverse reactions were compared between the two groups. Count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate was 95.12% in the observation group and 84.15% in the control group. There was significant difference between the two groups (χ2 = 5.316, P <0.05). In the observation group, the eradication rate of HP was 91.46% and that of the control group was 80.49%. There was significant difference between the two groups (χ2 = 4.096, P <0.05). The adverse reaction rates in the observation group and the control group were 7.32% and 6.10%, respectively, with no significant difference between the two groups (χ2 = 0.097, P> 0.05). Conclusion Omeprazole sequential therapy for HP-positive peptic ulcer clinical curative effect, HP eradication rate is high, patients with medication compliance, it is worth promoting the application of primary hospital.