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正常细胞经增生到恶性细胞,通常与胞核、胞浆及细胞表面内的分子水平的变化有关。这些变化可从正常细胞表面抗原如血型ABH抗原和主要组织相容性复合抗原等的丢失监测到。本文对一组确诊为正常膀胱粘膜、严重化生、乳头状癌、浸润癌、原位癌患者细胞表面β—2—微球蛋白的变化情况进行了研究。方法为对21例患者标本常规石蜡切片,作组织学检查观察形态学变化;平行切片作β—2—微球蛋白免疫过氧化酶组化染色,观察β—2—微球蛋白的存
Normal cells proliferate to malignant cells and are usually associated with changes in the nuclei, cytoplasm, and molecular levels within the cell surface. These changes can be monitored from the loss of normal cell surface antigens such as blood type ABH antigens and major histocompatibility complex antigens. In this paper, the changes of cell surface beta-2-microglobulin in a group of patients with normal bladder mucosa, severe metaplasia, papillary carcinoma, invasive carcinoma and carcinoma in situ were studied. Methods 21 paraffin sections of patients with histological examination to observe the morphological changes; parallel sections for β-2-microglobulin immunoperoxidase staining to observe the deposit of β-2-microglobulin