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目的:观察单硝酸异山梨酯注射液联合疏血通注射液治疗冠心病不稳定型心绞痛(UA)的临床疗效。方法:将60例患者随机分为2组各30例,在常规治疗的基础上,治疗组给予单硝酸异山梨酯注射液联合疏血通注射液治疗,对照组给予单硝酸异山梨酯注射液治疗,疗程均为2周。观察心绞痛疗效及发作次数、持续时间的变化以及硝酸甘油用量情况,并检测治疗前后血液流变学变化情况。结果:治疗组总有效率为90.0%,对照组为80.0%,2组比较,差异有显著性意义(P<0.05)。治疗后2组心绞痛发作次数、心绞痛持续时间以及硝酸甘油用量均有改善,与治疗前比较,差异有显著性意义(P<0.05);治疗后2组比较,差异亦有显著性意义(P<0.05)。治疗后2组血液流变学指标均明显改善,与治疗前比较,差异均有显著性意义(P<0.05);治疗后2组间比较,差异均有显著性意义(P<0.05)。结论:单硝酸异山梨酯注射液联合疏血通注射液治疗冠心病UA有较好的临床疗效。
Objective: To observe the clinical efficacy of isosorbide mononitrate injection combined with Shuxuetong injection in the treatment of unstable angina pectoris (UA). Methods: Sixty patients were randomly divided into two groups of 30 cases. On the basis of conventional treatment, the treatment group was given isosorbide mononitrate injection combined with Shuxuetong injection. The control group was given isosorbide mononitrate injection Treatment, treatment are 2 weeks. The curative effect of angina pectoris and the number of seizures, the duration of change and the dosage of nitroglycerin were observed. The changes of hemorheology before and after treatment were also observed. Results: The total effective rate was 90.0% in the treatment group and 80.0% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the number of angina attacks, the duration of angina pectoris and the dosage of nitroglycerin in both groups improved significantly compared with those before treatment (P <0.05). There was also significant difference between the two groups after treatment (P < 0.05). After treatment, the indexes of hemorheology in both groups were significantly improved, with significant difference compared with that before treatment (P <0.05). There was significant difference between the two groups after treatment (P <0.05). Conclusion: Isosorbide mononitrate injection combined with Shuxuetong injection in the treatment of coronary heart disease UA has a good clinical effect.