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目的调查体检人群的病史、身体指标、生化指标等因素与人群高尿酸血症(HUA)及HUA合并糖尿病(DM)的相关情况。方法调查2010年～2011年四川大学华西医院健康检查中心体检的成年受检者的疾病史、一般身体指标、生化指标及上腹部彩超。随机抽取1320例按尿酸及血糖水平分为正常组、单纯HUA组及HUA合并DM组,对三组进行相关因素分析。结果多因素多分类Logistic回归模型显示体重指数、收缩压、高甘油三酯、血肌酐、胱抑素C与HUA及HUA并发DM的发病危险性升高相关,而高密度脂蛋白(HDL-C)为两种疾病的保护性因素。结论 HUA在DM中发挥着重要的作用,两种疾病相互影响,应针对HUA和DM之间的相关因素,采取相应的措施,达到最佳防治的效果。
Objective To investigate the medical history, physical indexes, biochemical indexes and other related factors of crowd hyperuricemia (HUA) and HUA with diabetes mellitus (DM). Methods The disease history, general physical and biochemical indexes and upper abdominal ultrasonography of adult subjects undergoing physical examination in West China Hospital of Sichuan University from 2010 to 2011 were investigated. A total of 1320 cases were randomly divided into normal group, HUA group and HUA combined with DM group according to uric acid and blood glucose level, and the related factors were analyzed. Results Multivariate multiple classification Logistic regression model showed that body mass index, systolic blood pressure, triglyceride, serum creatinine, cystatin C were associated with the increased risk of HU with concurrent HUA and HUA. High density lipoprotein (HDL-C ) Is a protective factor for both diseases. Conclusions HUA plays an important role in DM. The two diseases affect each other. Corresponding measures should be taken according to the related factors between HUA and DM to achieve the best effect of prevention and treatment.