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目的:探讨载脂蛋白C3(ApoC3)基因多态性与代谢综合征(MS)之间的关系。方法:测量60例MS患者(MS组)及60例非MS患者(对照组)的空腹血脂血糖水平,应用聚合酶链反应对ApoC3基因-482T>C进行限制性片段长度多态性分析。结果:MS组与对照组在ApoC3基因多态位点频率分布上存在明显差异(P<0.01),-482T/C单核苷酸多态性位点T和C等位基因频率在MS组和对照组分别为55.8%、39.2%和44.2%、60.8%,均差异有统计学意义(均P<0.05)。结论:ApoC3-482T等位基因影响MS的发生与发展。
Objective: To investigate the relationship between apolipoprotein C3 (ApoC3) gene polymorphism and metabolic syndrome (MS). Methods: Fasting blood glucose and blood glucose were measured in 60 patients with MS (MS group) and 60 patients with non-MS (control group). Polymerase chain reaction was used to analyze the restriction fragment length polymorphism of ApoC3 gene -482T> C. Results: There was a significant difference in the frequency distribution of polymorphism of ApoC3 between MS group and control group (P <0.01). The frequency of T and C alleles at - 482T / C SNP was significantly higher in MS group and control group The control group were 55.8%, 39.2% and 44.2%, 60.8% respectively, with significant difference (all P <0.05). Conclusion: ApoC3-482T allele affects the occurrence and development of MS.