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作者综述了中医方剂小柴胡汤对循环系统的药理作用如下: 1.抗血小板聚集作用小柴胡汤(0.9g/kg)给小鼠灌服,其药效的高峰能抑制由2μmol/L胶原蛋白静注后诱导的血小板聚集作用的50％,其抑制效果相当(或稍高)于地塞米松(1mg/kg),阿司匹林(300mg/kg)或消炎痛(2mg/kg)的作用,且具有特有的双抑制高峰(服药后1h和5h)。 2.平衡血凝和纤溶作用实验方法、剂量同上,结果证实,它有显著的激活抗血栓素Ⅲ(凝血系统抑制因子)和α2-血浆溶酶抑制因子(纤溶系统抑制因子),
The author reviewed the pharmacological effects of Chinese medicine prescription Xiao Chai Hu Tang on the circulatory system as follows: 1. Anti-platelet aggregation Xiao Chai Hu Tang (0.9 g/kg) was given to mice by gavage, and the peak of its efficacy could be inhibited by 2 μmol/L of collagen. 50% of the platelet aggregation induced after intravenous injection has a similar (or slightly higher) inhibitory effect to dexamethasone (1 mg/kg), aspirin (300 mg/kg) or indomethacin (2 mg/kg), and has Unique dual inhibition peaks (1h and 5h after administration). 2. Balanced coagulation and fibrinolysis The experimental method and dose were the same as above, and the results confirmed that it had significant activation of anti-thromboxane III (thrombin inhibitor) and α2-plasmin inhibitor (fibrinolysis inhibitor).