论文部分内容阅读
转化生长因子-β(TGF-β)超家族是在脊椎动物和无脊椎动物中高度保守的一类细胞因子,其家族成员参与调节细胞增殖、分化、凋亡、黏附、骨骼形成、发育、炎症反应及创伤愈合等多种生命活动。SMAD家族成员是TGF-β信号的细胞内介导者,负责将TGF-β信号从细胞膜转入细胞核内,并激活靶基因的转录。创伤后TGF-β参与了皮肤愈合的炎症期、肉芽组织形成期和瘢痕形成期全过程。从信号转导通路不同环节干预和阻断,将对创伤愈合过程产生积极的作用。SMAD3在组织修复中的特殊作用可能成为今后探索难愈性创面的治疗热点。
Transforming growth factor-β (TGF-β) superfamily is a type of cytokine that is highly conserved in vertebrates and invertebrates. Members of its family are involved in the regulation of cell proliferation, differentiation, apoptosis, adhesion, bone formation, development and inflammation Reaction and wound healing and other life activities. The members of the SMAD family are intracellular mediators of TGF-β signaling, responsible for the transfer of TGF-β signaling from the cell membrane into the nucleus and activation of target gene transcription. TGF-βis involved in the inflammatory process of skin healing, granulation tissue formation and scarring of the whole process. Intervention and blocking from different aspects of the signal transduction pathway will have a positive effect on the wound healing process. The special role of SMAD3 in tissue repair may become the hot spot for the exploration of refractory wounds in the future.