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Hemminki通过流行病学调查,发现在某些金属工业部从业的妇女自发流产率增高。Nordstrm也曾报道瑞士北部地区妇女自发流产、多种畸形和低出生体重率增高与职业因素有关。这些报道都表明工业上使用的某些金属可影响人胚胎和胎儿的发育。随着金属工业的不断发展和妇女从业人数的逐年增长,作者认为有必要用动物实验研究金属对其胚胎和胎鼠发育的影响。 实验选用NMRI前未产仔的Albino小鼠,三雌一雄同笼饲养,发现阴道栓子时定为妊娠第1天。雌鼠于妊娠第3天或第8天分别给尾静脉注入不同种类各种浓度的金属溶液(AlCl_3、_6H_2O100或50mM;COCl_2·_6H_2P 5mM;Na_2
Hemminki, through an epidemiological survey, found that spontaneous abortion rates increased among women employed in certain metals ministries. Nordstrm also reported on spontaneous abortions, multiple deformities, and low birth weight among women in northern Switzerland in relation to occupational factors. These reports all indicate that certain metals used industrially affect the development of human embryos and fetuses. With the continuous development of the metal industry and the increasing number of women employed, the authors consider it necessary to use animal experiments to study the effects of metals on their embryonic and fetal rat development. Albino mice that had not been born before NMRI were selected in the experiment. Three female and one male were kept in the same cage, and the vaginal embolus was found as the first day of pregnancy. Female rats were injected with different kinds of metal solutions (AlCl_3, _6H_2O100 or 50mM; COCl_2 · 6H_2P 5mM; Na_2