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目的探讨妊娠期糖尿病(GDM)患者体质指数(BMI)、同型半胱氨酸与妊娠结局的相关性。方法选择2013年1月-2015年10月永康市第一人民医院收治的120例GDM患者为研究对象,根据患者BMI水平分为观察组(BMI≥25 kg/m~2)和对照组(<25 kg/m~2)。观察两组患者同型半胱氨酸水平和妊娠结局。结果观察组孕妇孕12周时同型半胱氨酸水平为(11.09±1.91)μmol/L,对照组为(8.92±1.57)μmol/L,两组比较,差异有统计学意义(t=6.774,P=0.000);BMI与同型半胱氨酸显著正相关(r=0.410,P=0.000)。观察组剖宫产率、巨大儿发生率、新生儿体质量均高于对照组,两组比较,差异有统计学意义(P=0.049、0.027、0.000)。两组妊娠周数、产后出血、头盆不称、胎位异常、宫缩乏力、胎膜早破和新生儿窒息发生率等比较,差异无统计学意义(均P>0.05)。结论 GDM患者BMI与同型半胱氨酸、剖宫产、巨大儿和新生儿体质量明显相关。
Objective To investigate the relationship between body mass index (BMI), homocysteine and pregnancy outcomes in patients with gestational diabetes mellitus (GDM). Methods One hundred and twenty patients with GDM admitted from January 2013 to October 2015 in Yongkang First People’s Hospital were divided into observation group (BMI≥25 kg / m ~ 2) and control group (< 25 kg / m ~ 2). Homocysteine levels and pregnancy outcomes were observed in both groups. Results The level of homocysteine in pregnant women in the observation group was (11.09 ± 1.91) μmol / L at 12 weeks of gestation and (8.92 ± 1.57) μmol / L in the control group, the difference was statistically significant (t = 6.774, P = 0.000). There was a significant positive correlation between BMI and homocysteine (r = 0.410, P = 0.000). Cesarean section rate, macrosomia rate and neonatal body weight were higher in the observation group than in the control group. There was significant difference between the two groups (P = 0.049, 0.027, 0.000). There was no significant difference in the number of gestational weeks, postpartum hemorrhage, cephalopelvic disproportion, fetal position abnormalities, uterine atony, premature rupture of membranes and neonatal asphyxia between the two groups (all P> 0.05). Conclusion BMI in patients with GDM is significantly associated with body mass of homocysteine, cesarean section, macrosomia and neonates.