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应用酶联免疫吸附法测定了３４例慢性肺心病急性期患者、３３例慢性支气管炎急性期患者及３０例对照组病人血清髓鞘碱性蛋白（ＭＢＰ）的含量。结果表明：肺心病组患者血清ＭＢＰ显著高于慢支炎组与对照组（Ｐ＜０．００１）．而慢支炎组与对照组则无明显差异（Ｐ＞０．０５）。经直线相关分析发现ＭＢＰ的含量与ＰａＣＯ＿２呈明显正相关，与ＰａＯ＿２及ｐＨ尚无明显相关性，提示ＭＢＰ的升高可能与低氧及高碳酸血症对脑组织的损伤有关。
The serum levels of MBP in 34 patients with acute pulmonary heart disease, 33 patients with chronic bronchitis and 30 patients with chronic bronchitis were measured by enzyme-linked immunosorbent assay. The results showed that the serum MBP in patients with pulmonary heart disease was significantly higher than those in chronic bronchitis and control groups (P <0.001). However, there was no significant difference between chronic bronchitis group and control group (P> 0.05). The linear correlation analysis showed that the content of MBP was positively correlated with PaCO_2, but not with PaO_2 and pH, suggesting that the increase of MBP may be related to hypoxia and hypercapnia on brain tissue damage.