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本文前瞻性研究154例2个月~14岁的发热(腋温≥38℃)患儿,以确定血清C 反应蛋白(CRP)浓度在评价发热性疾病时的诊断价值。凡急性中耳炎、急性扁桃体炎或近2周内用过抗生素及2个月龄以下的婴儿均除外。该154例中35例鼻咽分泌物经酶免疫法检出病毒抗原而证实为病毒感染(Ⅰ组),27例经血清和/或尿细菌培养、抗原检测或血清学检查等证实为细菌感染(Ⅱ组),92例由临床表现及疾病结局判断为可能有病毒感染(Ⅲ组)。另外,回顾性研究75例2个月~16岁经各种检查证实为细菌感染的患儿CRP 浓度。结果Ⅰ、Ⅲ组中75%的患儿CRP<20mg/L,90%的患儿CRP<40mg/L。而Ⅱ组中79%的患儿CRP≥40mg/L。该3组中,凡病
This prospective study of 154 children aged 2 months to 14 years old (axillary temperature ≥ 38 ℃) to determine the serum C-reactive protein (CRP) in the diagnosis of febrile disease. Except for acute otitis media, acute tonsillitis or antibiotics and infants under 2 months of age in the last 2 weeks. Of the 154 cases, 35 cases of nasopharyngeal secretions were confirmed as viral infection by enzyme immunoassay (group Ⅰ), 27 cases were confirmed as bacterial infection by serum and / or urine bacterial culture, antigen test or serological examination (Group Ⅱ), 92 cases were judged as possible viral infection by clinical manifestations and disease outcome (group Ⅲ). In addition, a retrospective study of 75 cases of 2 months to 16 years of various tests confirmed bacterial infection in children with CRP concentrations. Results In group Ⅰ and group Ⅲ, 75% of children had CRP <20mg / L and 90% of children had CRP <40mg / L. While 79% of children in group Ⅱ had CRP≥40mg / L. The three groups, where the disease