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目的:探讨更年灵汤治疗围绝经期综合征(MPS)的疗效。方法:将88例MPS女性随机分为2组。观察组46例患者,接受更年灵汤联合植物雌激素治疗。对照组42例患者,接受西医治疗。对比2组疗效、Kupperman指数(KI)评分、内分泌情况及免疫功能。结果:观察组总有效率为93.48%,对照组为73.81%,2组比较,差异有统计学意义(P<0.05)。2组治疗后KI评分均较治疗前改善(P<0.05),且观察组改善幅度优于对照组(P<0.05)。2组治疗后血清雌二醇(E2)水平均较治疗前上升(P<0.05),且观察组上升幅度优于对照组(P<0.05)。2组治疗后促卵泡刺激素(FSH)、促黄体生成素(LH)水平均较治疗前降低(P<0.05),且观察组降低幅度优于对照组(P<0.05)。2组治疗后白细胞介素-2(IL-2)、血浆-内啡肽(β-EP)、5-羟色胺(5-HT)水平均较治疗前上升(P<0.05),且观察组上升幅度优于对照组(P<0.05)。结论:采取更年灵汤联合植物雌激素对MPS进行治疗,可调节女性内分泌激素表达,改善免疫功能,减轻临床症状,提高治疗效果。
Objective: To investigate the effect of Gengnianling Decoction on perimenopausal syndrome (MPS). Methods: 88 MPS women were randomly divided into two groups. 46 patients in the observation group were treated with Gengnianling Decoction combined with phytoestrogen. The control group of 42 patients received Western medical treatment. The curative effect, Kupperman index (KI) score, endocrine status and immune function were compared between the two groups. Results: The total effective rate was 93.48% in the observation group and 73.81% in the control group. There was significant difference between the two groups (P <0.05). The scores of KI in both groups were better than those before treatment (P <0.05), and the improvement in the observation group was better than that in the control group (P <0.05). Serum estradiol (E2) levels in both groups were significantly higher than those before treatment (P <0.05), and the increase in the observation group was better than that in the control group (P <0.05). The FSH and LH levels of the two groups were lower than those before treatment (P <0.05), and the reduction rate of the observation group was better than that of the control group (P <0.05). The levels of IL-2, β-EP and 5-HT increased in both groups after treatment (P <0.05), and the observation group increased Magnitude better than the control group (P <0.05). Conclusion: The treatment of MPS with Gengnianling Decoction and phytoestrogens can regulate the expression of female endocrine hormones, improve the immune function, relieve clinical symptoms and improve the therapeutic effect.