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目的评价血清胱抑素C(CysC)在高胆红素血症患儿肾损害中的意义。方法收集54例新生儿高胆红素血症患儿(轻度黄疸组19例,中重度黄疸组35例)和20例正常足月新生儿的血清,以生化分析法测定总胆红素(TBIL)、胱抑素C(CysC)、尿素氮(BUN)、肌酐(SCr)含量,并进行相关的统计学分析。结果中重度黄疸组CysC、BUN、SCr浓度明显高于轻度黄疸组和正常对照组(P<0.05);中重度黄疸组CysC的异常率显著高于BUN和SCr的异常率(P<0.05)。结论血清CysC是评价高胆红素血症新生儿早期肾损害一项敏感可靠的指标。
Objective To evaluate the significance of serum cystatin C (CysC) in renal damage in children with hyperbilirubinemia. Methods Serum samples were collected from 54 neonates with hyperbilirubinemia (mild jaundice in 19 cases, moderate to severe jaundice in 35 cases) and 20 normal term newborns. The levels of total bilirubin TBIL, CysC, BUN and SCr were measured and analyzed statistically. Results The levels of CysC, BUN and SCr in moderate and severe jaundice group were significantly higher than those in mild jaundice group and normal control group (P <0.05). The abnormal rate of CysC in moderate and severe jaundice group was significantly higher than that in BUN and SCr (P <0.05) . Conclusion Serum CysC is a sensitive and reliable index for evaluating early renal damage in neonates with hyperbilirubinemia.