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目的:探讨黄连解毒汤对荷瘤小鼠免疫调节作用。方法:选择H22肝癌小鼠模型,通过检测免疫指标,研究黄连解毒汤对正常小鼠和模型小鼠免疫反应的影响。结果:实验组小鼠的自然杀伤细胞(NK)杀伤活性及T细胞分泌白细胞介素-4(IL-4)的能力均有显著增高(P<0.01,P<0.001)。结论:黄连解毒汤能增强荷瘤小鼠体内NK细胞的杀伤功能及体液免疫功能。
Objective: To investigate the immunoregulatory effect of Huanglian Jiedu Tang on tumor-bearing mice. Methods: The H22 liver cancer mouse model was selected and the effect of Huanglian Jiedu Decoction on the immune response in normal mice and model mice was examined by detecting immune indicators. RESULTS: The killing activity of natural killer (NK) cells and the ability of T cells to secrete interleukin-4 (IL-4) were significantly increased in the experimental group (P<0.01, P<0.001). Conclusion: Huanglian Jiedu Decoction can enhance the killing and humoral immunity of NK cells in tumor-bearing mice.