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目的:比较宫颈癌术后的三维适形放疗(3D-CRT)和调强放射治疗(IMRT)放射治疗计划的剂量学差异。方法:使用Elekta公司的PrecisePLAN Release2.11计划系统设计常规四箱形野(3D-CRT)和调强放疗(IMRT)计划。通过剂量-体积直方图比较二者的放射物理参数,评价其应用价值。结果:IMRT计划中靶区平均剂量略高于3D-CRT计划中的相应值,其靶区适形度明显占优。同时,IMRT计划中的膀胱、直肠、小肠、股骨头等危险器官受到的平均剂量低于3D-CRT计划中的相应值,除右股骨头受到的平均剂量差异没有统计学意义,其它数据的差异都具有统计学意义。结论:对于宫颈癌术后患者的放射治疗,IMRT技术在保证肿瘤放射剂量的同时最大限度地减少了危险器官的照射剂量,减少了并发症的发生,应该更广泛地应用于临床。
Objective: To compare the dosimetry differences between 3D-CRT and IMRT radiotherapy after cervical cancer surgery. Methods: Design a conventional 3D-CRT and IMRT plan using Elekta’s PrecisePLAN Release 2.1 planning system. The dose-volume histograms were compared for their radiophysical parameters to evaluate their application value. Results: The average target dose in IMRT plan was slightly higher than that in 3D-CRT plan, and the target conformality was obviously superior. At the same time, the average dose of IMRT in the dangerous organs such as the bladder, rectum, small intestine and femoral head was lower than the corresponding value in the 3D-CRT plan. There was no significant difference in the average dose received in the right femoral head. Other data differences All have statistical significance. Conclusion: IMRT can reduce the dose of dangerous organs and reduce the incidence of complications while ensuring the radiation dose of tumor for patients with cervical cancer. It should be applied more widely in clinic.