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目的 观察西立伐他汀对高胆固醇患者单核 内皮细胞黏附的影响 ,以探讨他汀类药物其他可能的抗动脉粥样硬化作用。方法 检测 17高胆固醇患者服用西立伐他汀前后的外周血单核细胞与培养人脐静脉内皮细胞的黏附率。结果 17例高胆固醇患者 ,男 15例 ,女 2例 ,年龄 36～ 5 4岁。口服西立伐他汀 0 .3mg/d ,8周后 ,高胆固醇患者的总胆固醇降低 19.6 % (P =0 .0 0 1) ,低密度脂蛋白胆固醇 (LDL C)降低 31.1% (P =0 .0 0 1) ,甘油三酯 (TG)降低 5 .1% (P =0 .0 0 97) ,单核 内皮细胞黏附率降低 2 7.7% (P =0 .0 0 1) ;高胆固醇患者的单核 内皮细胞黏附率与总胆固醇 (r=0 .6 744 ,P =0 .0 0 3)、LDL C(r=0 .6 175 ,P =0 .0 0 8)、TG(r=0 .712 7,P =0 .0 0 13)呈正相关性 ;内皮细胞先经西立伐他汀孵育后 ,对单核细胞的黏附率与高胆固醇患者服药前的黏附率差异无显著性 (P =0 .7470 ) ;单核细胞经西立伐他汀孵育后 ,与内皮细胞的黏附率较服药前降低 12 .9% (P =0 .0 0 1) ,但仍较服西立伐他汀 8周后高 2 0 .7% (P =0 .0 0 1)。结论 高胆固醇患者经西立伐他汀治疗血脂水平下降后 ,其单核 内皮细胞黏附率随之降低 ,西立伐他汀可直接作用于单核细胞而降低其与内皮细胞的黏附性
Objective To observe the effect of cerivastatin on the adhesion of monocytes to hypercholesterolemia in order to explore the possible anti-atherosclerotic effects of statins. Methods The adhesion rate of peripheral blood mononuclear cells and human umbilical vein endothelial cells before and after administration of cerivastatin in 17 hypercholesterolaemic patients were measured. Results 17 patients with high cholesterol, 15 males and 2 females, aged 36 to 54 years old. Oral administration of cerivastatin 0.3 mg / d resulted in a 19.6% (P = 0.001) decrease in total cholesterol and an increase in low density lipoprotein cholesterol (LDL C) of 31.1% after 8 weeks (P = 0 (P0.01). The adhesion rate of mononuclear endothelial cells decreased by 7.76% (P = 0.010). In patients with hypercholesterolemia (R = 0.6644, P = 0.0030), LDL C (r = 0.675, P = 0.080), TG (r = 0.77127, P = 0.013). There was no significant difference between the adhesion rate of monocytes and the rate of adhesion of monocytes before administration of cerivastatin (P = 0.7470). After monocytes were incubated with cerivastatin, the adhesion rate to endothelial cells was decreased by 12.9% (P = 0.010) compared with that before administration, Week high 2.07% (P = .0 0 1). Conclusions In patients with hypercholesterolemia, the monocyte-endothelial cell adhesion rate decreases after treatment with ceritumin, and cerivastatin can directly affect the monocyte adhesion to endothelial cells