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目的:观察艾迪注射液联合化疗治疗晚期肺癌的临床疗效。方法:将136例晚期肺癌患者随机分为治疗组70例和对照组66例。对照组在第1,8天给予重酒石酸长春瑞滨注射液25 mg.m-2,第1～3天给予顺铂30 mg.m-2;治疗组化疗方案同对照组,同时给予艾迪注射液50 mL加入5%葡萄糖注射液450 mL中,gtt,qd;连用10 d为1周期,每间隔21 d重复治疗,共3～4个周期。2组病例均给予格拉司琼止吐治疗。结果:近期疗效有效率治疗组为68.57%,对照组39.39%,2组比较差异有显著性(P<0.05);生活质量改善率(等级提高)治疗组为77.14%,对照组为48.48%,治疗组优于对照组(P<0.05);血象变化和胃肠道毒性反应比较,除厌食差异无显著性外,其余差异均具有显著性(P<0.05),治疗组优于对照组。结论:艾迪注射液可作为一种有效的化疗增效减毒剂,配合化疗治疗中晚非小细胞期肺癌。
Objective: To observe the clinical effect of Aidi injection combined with chemotherapy in the treatment of advanced lung cancer. Methods: 136 patients with advanced lung cancer were randomly divided into treatment group (70 cases) and control group (66 cases). The control group received vinorelbine tartrate injection 25 mg.m-2 on day 1, day 8, and cisplatin 30 mg.m-2 on day 1 to 3. The chemotherapy in the treatment group was the same as the control group, Injection 50 mL added 5% glucose injection 450 mL, gtt, qd; d 10 for 1 cycle, 21 d repeated intervals for treatment, a total of 3 to 4 cycles. Two groups of patients were given granisetron antiemetic treatment. Results: The effective rate of the treatment group was 68.57% and the control group was 39.39%, the difference was significant between the two groups (P <0.05); the quality of life improvement (grade) was 77.14% in the treatment group and 48.48% in the control group, The treatment group was better than the control group (P <0.05). Compared with the control group, the changes of the blood group and the gastrointestinal tract toxicity showed no significant difference except the anorexia (P <0.05). Conclusion: Aidi injection can be used as an effective chemotherapy attenuator, combined with chemotherapy for the treatment of non-small cell lung cancer.