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FOXL2是翼状螺旋/叉头转录因子超家族成员,FOXL2基因是第一个被认定在维持卵巢功能方面发挥重要作用的常染色体基因,在眼睑和卵巢颗粒细胞表达,参与脊椎动物雌性性腺早期发育与分化,对卵泡生长发育起重要调节作用。其基因突变可致卵巢早衰、女性不孕。本文综述了FOXL2的研究进展,包括其结构特点、组织中的表达、在女性生殖系统中的生物作用及信号传导通路的调节。
FOXL2 is a member of the superfamily of pterygial / forkhead transcription factors. FOXL2 is the first autosomal gene identified as playing an important role in maintaining ovarian function. It is expressed in eyelid and ovarian granulosa cells and is involved in the early development of female gonads in vertebrates Differentiation, the growth and development of follicles play an important regulatory role. Its gene mutation can cause premature ovarian failure, female infertility. This review summarizes the advances in FOXL2, including its structural features, tissue expression, biological roles in the female reproductive system, and regulation of signaling pathways.