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Graves病是一类有T细胞介导的器官特异性自身免疫性疾病,该病是由于血液中存在一种刺激物兴奋甲状腺而引起,具有高代谢,弥漫性甲状腺肿大和突眼三大特点。近期的研究表明,维生素D在机体内的作用不仅体现在对钙磷代谢的条件,也具有免疫调节作用,可调节各种免疫炎性细胞的分化和作用,从而影响自身免疫炎性反应进程。目前临床研究显示,患者血清25羟基维生素D水平与Graves病的发生、发展有一定关联。为了更好的阐述Graves病的发病机制,对血清25羟基维生素D水平与Graves病相关性的研究将有着重要意义。为此,本文对近期国内外开展的Graves病与25羟基维生素D关系研究的进展做一综述,力求能够为临床Graves病的发病机制研究和治疗提供参考。
Graves disease is a class of T cell-mediated organ-specific autoimmune diseases caused by the presence of an irritant in the blood that excites the thyroid gland and has three major hallmarks of high metabolism, diffuse goiter and exophthalmos. Recent studies have shown that the role of vitamin D in the body is not only reflected in the conditions of calcium and phosphorus metabolism, but also has immunomodulatory effects, can regulate a variety of immune inflammatory cell differentiation and role, thus affecting the process of autoimmune inflammatory response. The current clinical studies have shown that serum 25-hydroxyvitamin D levels and Graves disease occurrence and development are related. In order to elucidate the pathogenesis of Graves disease, it is of great significance to study the relationship between serum 25-hydroxyvitamin D and Graves’ disease. Therefore, this review summarizes the recent progress in the study of the relationship between Graves ’disease and 25-hydroxyvitamin D in the world, and seeks to provide a reference for the study of the pathogenesis of Graves’ disease.