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结直肠癌是世界范围内的高发癌症,其发病机理尚不明确。大量研究数据表明,基因突变、表观遗传学的改变、饮食习惯以及生活方式等均是结直肠癌发生发展的高危因素。目前,普遍认为慢性炎症在肿瘤的发生发展中起重要作用。白介素17主要由T细胞的亚型Th17细胞分泌产生,能够促进肿瘤相关性炎症,使肿瘤细胞逃避免疫监控。已在胃癌、宫颈癌、食管癌、非小细胞肺癌、肝细胞肝癌、卵巢癌、黑色素瘤、淋巴瘤、乳腺癌、前列腺癌、结直肠癌等多种恶性肿瘤中发现白介素17呈高表达。现有研究表明,白介素17与肠炎和结直肠癌的发生发展密切相关。尽管尚存在争议,多数学者认为白介素17在结直肠癌的发生发展中起促进作用。本文将近年来关于IL-17在结直肠癌的发生发展中的作用以及其与结直肠癌的预后的研究成果进行总结。
Colorectal cancer is a worldwide high incidence of cancer, the pathogenesis is not yet clear. A large number of data show that genetic mutations, epigenetic changes, diet and lifestyle are the risk factors for the development of colorectal cancer. At present, it is generally accepted that chronic inflammation plays an important role in the development of tumors. Interleukin 17 is secreted mainly by Th17 cells, a subset of T cells, which promotes tumor-associated inflammation and allows tumor cells to evade immune surveillance. Interleukin 17 has been found to be highly expressed in gastric cancer, cervical cancer, esophageal cancer, non-small cell lung cancer, hepatocellular carcinoma, ovarian cancer, melanoma, lymphoma, breast cancer, prostate cancer, colorectal cancer and other malignancies. Existing studies show that interleukin 17 and colitis and colorectal cancer are closely related to the occurrence and development. Although still controversial, most scholars believe that interleukin 17 can promote the development of colorectal cancer. This article summarizes the role of IL-17 in the development and progression of colorectal cancer and its relationship with the prognosis of colorectal cancer in recent years.