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目的分析慢性重型病毒性肝炎合并糖尿病临床转归上的特点。方法回顾性分析慢性重型病毒性肝炎合并糖尿病患者肝功能各项指标、各种并发症以及转归。结果在相同住院时间段慢性重型病毒性肝炎合并糖尿病组患者胆红素值较无合并糖尿病组高(P<0.05),且合并糖尿病组患者起病后总胆红素增至峰值的时间延长(51.4±36.7Vs40.9±34.6d,P=0.039),住院期间总胆红素恢复的速率更缓慢(P<0.001)。合并糖尿病组患者更容易并发感染、肝肾综合症、肝性脑病(P<0.05)。合并糖尿病组患者病情未愈或死亡的比例更高(54/87Vs46/121,P=0.001)。结论慢性重型病毒性肝炎合并糖尿病导致病情不易恢复,预后差。易并发感染、肝肾综合症、肝性脑病等,总胆红素增至峰值所需的时间延长,恢复缓慢。
Objective To analyze the clinical features of chronic severe viral hepatitis complicated with diabetes. Methods Retrospective analysis of various indicators of liver function, complications and outcomes in patients with chronic severe viral hepatitis and diabetes mellitus. Results The bilirubin value in patients with chronic severe viral hepatitis with diabetes mellitus was significantly higher than that in patients without diabetes mellitus (P <0.05) at the same hospitalization time, and prolonged the time when total bilirubin peaked 51.4 ± 36.7Vs40.9 ± 34.6d, P = 0.039). The rate of total bilirubin recovery during hospitalization was slower (P <0.001). Patients with diabetes were more likely to be complicated by infection, hepatorenal syndrome, hepatic encephalopathy (P <0.05). Patients with diabetes mellitus had a higher proportion of patients who did not heal or die of illness (54/87 vs 46/121, P = 0.001). Conclusions Chronic severe viral hepatitis with diabetes leads to the condition is not easy to recover, the prognosis is poor. Easily complicated with infection, hepatorenal syndrome, hepatic encephalopathy, total bilirubin increased to the peak time required to recover slowly.