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流行性出血热以发热、休克、充血出血和急性肾功能衰竭为主要表现,病程较长。急性肾功能衰竭可合并全身多脏器衰竭,大量细胞因子和炎症介质的参与使机体处于免疫失衡状态,短期存活率差,患者死亡率随衰竭器官数的增加而增加,可高达70%。当前急性肾损伤导致全球范围内每年数百万重症患者死亡,发病率正逐年上升。连续性肾脏替代治疗具有血流动力学稳定、溶质清除率高、为重症患者的营养支持提供治疗“空间”和清除炎性介质等优势。
Epidemic hemorrhagic fever with fever, shock, congestion and acute renal failure as the main performance, longer duration. Acute renal failure can be combined with systemic multiple organ failure, a large number of cytokines and inflammatory mediators in the immune imbalance in the body state, short-term survival rate is poor, the patient mortality increased with the number of depleted organs, up to 70%. The current acute kidney injury has led to the deaths of millions of critically ill patients worldwide every year, and the incidence is on the rise. Continuous renal replacement therapy offers hemodynamic stability and high solute clearance to provide “space” and nutritional benefits for critically ill patients.