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目的:研究鼻咽癌高发区EB病毒感染者肿瘤坏死因子(TNF-α)及白介素2(IL-2)水平。方法:免疫酶法检测血清EBVCA-IgA确定EB病毒感染者44例为观察组,以健康人18例作为对照组,ELISA法测定血清TNF-α及IL-2水平;比较其血清TNF-α及IL-2水平。结果:EB病毒感染者及健康对照者TNF-α分别为(37.5±18.7)pg/mL及(23.2±9.6)pg/mL,P<0.01;而IL-2分别为(14.4±7.1)pg/mL及(18.7±6.4)pg/mL,P<0.05。结论:EB病毒感染者肿瘤坏死因子水平增高而白介素2水平低下。
Objective: To study the levels of tumor necrosis factor (TNF-α) and interleukin-2 (IL-2) in patients with Epstein-Barr virus (EBV) infection in high incidence areas of nasopharyngeal carcinoma. Methods: Serum EBVCA-IgA was detected by enzyme-linked immunosorbent assay (ELISA) in 44 patients with Epstein-Barr virus (EBV) infection. Eighteen healthy subjects were used as control group. Serum TNF-α and IL-2 levels were measured by ELISA. IL-2 levels. Results: The levels of TNF-α in EBV-infected and healthy controls were (37.5 ± 18.7) pg / mL and (23.2 ± 9.6) pg / mL, mL and (18.7 ± 6.4) pg / mL respectively, P <0.05. Conclusion: The levels of tumor necrosis factor and Epstein-Barr virus 2 are lower in patients with EBV infection.