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造成肾脏损害的药物已知有抗菌素、抗风湿药、类固醇类、解热镇痛剂、口服避孕药、甘草制剂等。包括抗菌素在内的化疗药物在各科领域内应用很广,用量亦很大。一、氨基甙类(AMG类) AMG类主要从肾脏排泄,对肾脏的损害已是人所共知的了。常用AMG类对肾脏的损害程度比多烯类(二性霉素乙)、多肽类(粘菌素、多粘菌素乙等)要轻,临床使用时必须十分慎重。各种抗菌素在肾脏的作用部位现已搞清,详细的作用机理则尚未阐明。AMG类造成肾脏损害的部位主要在近曲小管,初期
Drugs that cause kidney damage are known as antibiotics, anti-rheumatic drugs, steroids, antipyretic analgesics, oral contraceptives, licorice preparations and the like. Chemotherapy drugs, including antibiotics, are widely used and widely used in various fields. A, aminoglycosides (AMG class) AMG class mainly excreted from the kidneys, damage to the kidneys is well known. Commonly used AMG class of kidney damage than polyene (amphotericin B), peptides (colistin, polymyxin B, etc.) to be light, the clinical use must be very careful. A variety of antibiotics in the role of the kidney site has now been clarified, the detailed mechanism of action has not yet been clarified. AMG causes kidney damage mainly in the proximal tubule, early stage