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将β－半乳糖苷酶、ＨＢｓＡｇ以及恶性疟原虫两种重组复合抗原ＨＢｓＡｇ／４５肽与β－半乳糖苷酶／４５肽分别免疫小鼠。然后测定免疫小鼠脾细胞在ＣｏｎＡ和恶性疟原虫红内期全虫抗原诱导下产生ＩＬ－２的水平。结果表明，ＨＢｓＡｇ／４５肽免疫组ＩＬ－２水平明显高于β－半乳糖苷酶／４５肽免疫组。结果提示，ＨＢｓＡｇ颗粒有可能成为疟疾疫苗良好的蛋白载体。
The mice were immunized with HBsAg / 45 peptide and β-galactosidase / 45 peptide, respectively, of β-galactosidase, HBsAg and Plasmodium falciparum. The levels of IL-2 produced by immunized mouse spleen cells upon induction by Con A and Plasmodium falciparum erythrocytic stages of whole worms were then determined. The results showed that the IL-2 level of HBsAg / 45 peptide immunization group was significantly higher than that of β-galactosidase / 45 peptide immunization group. The results suggest that HBsAg particles may become a good protein carrier for malaria vaccine.