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Background The ideal post-gastrectomy reconstruction procedure should maintain the normal digestive function and restore intestinal transit to improve the patient quality of life.The aim of this study was to evaluate the effects of integral continual jejunal interposition after subtotal gastrectomy on the nutritional status,glucose levels,and gastric-intestinal motility.Methods The study investigated the effects of the integral continual jejunal interposition,the Billroth Ⅰ and Billroth Ⅱ operations,and the isolated jejunal interposition following subtotal distal gastrectomy on the blood glucose,insulin,routine blood parameters,liver function,and myoelectrical activity in Beagle dogs.Results The weights of the dogs decreased during the first post-operative weeks.Dogs in the integral continual jejunal interposition,Billroth Ⅰ,and Billroth Ⅱ groups gained significantly more weight by 8 weeks.The prognosis nutrition index of the dogs decreased in the first 2 post-operative weeks and increased significantly by 4 weeks in the integral continual jejunal interposition and Billroth Ⅰ groups.The group with duodenal exclusion (Billroth Ⅱ) had significantly higher glucose levels compared to the normal control group.The insulin curve was much higher in dogs that underwent the Billroth Ⅰ,continual jejunal interposition,and isolated jejunal interposition than the Billroth Ⅱ and normal groups.The frequencies of fasting and postprandial jejunal pacesetter potentials (PPs) were greater in the continual jejunal interposition and Billroth Ⅰ groups than that in the isolated jejunal interposition and Billroth Ⅱ groups.The percentage of aboral propagation of PPs was greater in the continual jejunal interposition group than the Billroth Ⅰ,isolated jejunal interposition,and Billroth Ⅱ groups.Conclusion Continual jejunal interposition after subtotal gastrectomy avoids jejunal transection,maintains the duodenal passage and food storage bags,and reduces the influence of blood glucose and insulin.