Therapeutic targeting of epidermal growth factor receptor in human cancer： successes and limitations

• 作 者: Jill Wykosky Tim Fenton Frank
• 机 构: LudwigInstituteforCancerResearch,DepartmentofMedicine
• 出 处: 癌症：英文版
• 发表日期: 2011年1期
• 关键词: 表皮生长因子受体 靶向治疗 癌症 人类 酪氨酸激酶抑制剂 信号转导通路 恶性肿瘤 临床治疗 EGFR targeting therapeutic
• 基金项目: AcknowledgmentThis work was supported by an award from the Goldhirsh Foundation, NIH Grant P01-CA95616, NIH （NINDS） Fellowship Award F32NS066519, Fellow Award from the National Foundation for Cancer R

Epidermal growth fac tor receptor (EGFR) is one of the most commonly altered genes in human cancer by way of over-expression, amplification, and mutation. Targeted inhibition of EGFR activity suppresses signal transduction pathways which control tumor cel