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Atrial fibrillation(AF)is the most common cardiacarrhythmia in man,and epidemiological study hasshown the close relationship between the incidence of AFand aging.Although the effects of aging on atrialelectrophysiology have been investigated in humans andanimal models,the electrophysiological changes thatmake the atria of aged individuals more susceptible to AFthan those of adults remain poorly understood.AF is areentrant arrhythmia,and the potential importance ofdispersion of effective refractory period(ERP)for theinduction and maintenance of reentry has long beenrecognized,In this study,we measured the dispersionof ERP and the underlying ionic mechanism in the atriaof old and adult canines.
Atrial fibrillation (AF) is the most common cardiacarrhythmia in man, and epidemiological study hasshown the close relationship between the incidence of AF and aging. Although the effects of aging on atrialelectrophysiology have been investigated in humans and animal models, the electrophysiological changes that that make the atria of age individuals more susceptible to AFthan those of adults remain poorly understood. AF isentrant arrhythmia, and the potential importance of discrete of of refractory period (ERP) for the induction and maintenance of reentry has long beenrecognized, In this study, we measured the dispersion of ERP and the the underlying ionic mechanism in the atria of old and adult canines.