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由于茶碱的有效血药浓度范围较窄(5～15ug/ml),因此研究食物对其安全性的影响是必要的。在1986年Steffensen和Pedersen曾报道过茶碱的所谓“剂量累积效应”:8名病人在给其缓释制剂和食物同服后有3名病人出现茶碱中毒的血药浓度。本文通过12名健康男
As the theophylline effective blood concentration range is narrow (5 ~ 15ug / ml), so the study of the impact of food on its safety is necessary. The so-called “cumulative dose effect” of theophylline was reported by Steffensen and Pedersen in 1986: Eight patients developed theophylline plasma concentrations in three patients after they were given their sustained release formulation and food. This article by 12 healthy men