膳食钙对高血压病的降压机制研究进展

• 作 者: 丁烨 王枫
• 机 构: 第四军医大学营养与食品卫生学教研室,第四军医大学营养与食品卫生学教研室 陕西西安710032,陕西西安710032
• 出 处: 国外医学(卫生学分册)
• 发表日期: 2006年06期
• 关键词: 膳食钙 降压机制

流行病学研究提示高血压病人膳食中钙的缺乏可能与其发病有关,而补充膳食钙则可能有辅助降血压的效果。过去20年间,许多人体实验的结果证实,膳食钙在血压调节中有重要作用。补充钙可使某些血压正常者和高血压受试者的血压有短期的轻微下降;对其机制的研究表明可能与一氧化氮和一氧化氮合酶有关,但是具体机制尚不清楚。

Epidemiological studies suggest that the lack of calcium in the diet of hypertensive patients may be related to their pathogenesis, while dietary calcium supplement may have the effect of lowering blood pressure. The results of many human experiments over the past two decades confirm that dietary calcium plays an important role in the regulation of blood pressure. Calcium supplementation may cause some short-term and slight decreases in blood pressure in some normotensives and hypertensive subjects; studies of its mechanism suggest that nitric oxide and nitric oxide synthase may be involved, but the exact mechanism remains unclear.