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肝纤维化是各种慢性肝病向肝硬变发展的必经阶段,业已证实血清透明质酸(HA)、层粘连蛋白(LN)前Ⅲ胶原(PCⅢ)含量变化能反映肝细胞损害和肝纤维化程度。白介素1β(IL-1β)、干扰素-γ(IFN-γ)与肝纤维化的关系国内文献报告尚属少见,我们通过检测IL-1β,IFN-γ在病毒性肝炎患者血清水平的变化,结合肝脏病理学资料探讨其在肝纤维化机制中的作用。 1 材料和方法 1.1 材料各种肝病80例,其中急性肝炎(AH)10例,慢性肝
Liver fibrosis is a necessary stage for the development of various chronic liver diseases toward cirrhosis. It has been demonstrated that changes in the levels of serum hyaluronic acid (HA) and laminin (LN) pre-collagen (PCIII) can reflect hepatocellular damage and liver fibrosis Degree of. The relationship between interleukin 1β (IL-1β), interferon-γ (IFN-γ) and liver fibrosis is still rare in our country. We detected the changes of serum levels of IL-1β and IFN-γ in patients with viral hepatitis, Combined with liver pathology data to explore its role in the mechanism of liver fibrosis. 1 Materials and Methods 1.1 Materials 80 cases of various liver diseases, including acute hepatitis (AH) in 10 cases, chronic liver