Efficacies of β-L-D4A against Hepatitis B virus in 2.2.15 cells

• 作 者: Lin-Lin Gao Xiao-Yan Wang Ju-S
• 机 构: InstituteofLiverDiseases
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2008年8期
• 关键词: 乙肝 表面抗原 药物疗法 抗病毒活性 23＇-didehydro-23＇-dideoxyadenosine 2.2.15 cells Hepatitis B v
• 基金项目: Supported by Grants from the National Natural Science Foundation of China, Key Program, No. 30330680,ACKNOWLEDGMENTS We thank Professor Yung-Chi Cheng for the kind gift of 2.2.15 cells and 3TC. We als

AIM:To investigate the antiviral effect of beta-L-enantiomer of 2',3'-didehydro-2',3'-dideoxyadenosine (β-L-D4A) on 2.2.15 cells transfected with the hepatitis B virus (HBV) genome. METHODS:Lamivudine (3TC) as a positive control. Then, HBV