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目的 探讨妊娠合并肝内胆汁瘀积症 (ICP)孕妇 ,胎儿血清胆酸 (CA)含量与胎儿窘迫的关系 ;ICP与新生儿黄疸的关系。方法 选择 48例ICP病人为实验组 ,5 0例正常孕妇为对照组 ,分别测定孕妇及新生儿脐血胆酸水平及新生儿血清胆红素水平。结果 ICP孕妇及其胎儿脐血CA水平均较对照组明显高 ,且胎儿窘迫发生率亦增高 ;实验组新生儿血清胆红素水平明显增高 ,且 72h内黄疸发生率增高。结论 建议测定CA水平作为预测ICP胎儿预后的一项指标 ;母体发生ICP可使新生儿黄疸发生率增高。
Objective To investigate the relationship between fetal serum bile acid (CA) and fetal distress in pregnant women with intrahepatic cholestasis (ICP) and the relationship between ICP and neonatal jaundice. Methods 48 ICP patients were selected as the experimental group and 50 normal pregnant women as the control group. The levels of uric acid and bilirubin in pregnant women and their newborns were measured respectively. Results The levels of CA in pregnant women and their umbilical cord blood were significantly higher than those in the control group and the incidence of fetal distress was also increased. The serum bilirubin level was significantly higher in experimental group and the incidence of jaundice was higher in 72 hours. Conclusions It is recommended to measure the level of CA as an index to predict the prognosis of ICP fetus. The occurrence of ICP may lead to an increase in the incidence of neonatal jaundice.