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本文研究肺肿瘤组织中雌激素受体（ＥＲ）和孕激素受体（ＰＲ）的水平。小鼠注射乌拉坦和已烯雌酚诱导肺肿瘤，采用免疫组化方法测定肺肿瘤中的ＥＲ、ＰＲ。乌拉坦和已烯雌酚联合诱导的肺恶性肿瘤的ＥＲ、ＰＲ阳性率比单纯乌拉坦诱导的为高，说明已烯酚可能可提高癌组织性激素受体含量。ＥＲ阳性率与恶性肿瘤大小有关，但与良性肿瘤大小无关；ＰＲ阳性率与良、恶性肿瘤大小均无关。恶性肿瘤的ＥＲ、ＰＲ阳性率（分别为４６３％和５２５％）显著高于良性肿瘤（分别为１８８％和２０２％）。良性肿瘤ＥＲ、ＰＲ同时阳性率为１１６％，同时阴性率为７２５％；恶性肿瘤ＥＲ、ＰＲ同时阳性率为３１３％，同时阴性率为３２５％。结果提示肺肿瘤可能为性激素依赖性肿瘤，并为肺癌的临床内分泌治疗提供依据
This article examines the levels of estrogen receptor (ER) and progesterone receptor (PR) in lung tumor tissue. Mice were injected with urethane and diethylstilbestrol to induce lung tumors. ER and PR in lung tumors were measured by immunohistochemistry. The positive rates of ER and PR in malignant tumors induced by urethane and diethylstilbestrol were higher than those induced by urethane alone, indicating that ketene may increase the content of sex hormone receptors in cancer tissues. The positive rate of ER was related to the size of malignant tumors, but not to the size of benign tumors. The positive rate of PR was not related to the size of benign and malignant tumors. The positive rates of ER and PR in malignant tumors (46. 3% and 52.5%, respectively) were significantly higher than those in benign tumors (18.8% and 20.2%, respectively). The positive rate of ER and PR in benign tumor was 11.6%, and the negative rate was 72.5%. The positive rate of ER and PR in malignant tumor was 31. 3%, and the negative rate was 32.5%. The results suggest that lung cancer may be a sex hormone-dependent tumor and provide a basis for clinical endocrine therapy of lung cancer