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本文研究小鼠受~(60)Co γ线4000、8000和16000拉德全身一次照射后小脑的组织学和超微结构变化。发现最突出的变化是颗粒细胞核发生皱缩,仅个别细胞发生坏死。1600拉德组发生明显的中枢神经系统症状,颗粒细胞核皱缩率达44.95％,肯定属脑型放射病;8000拉德组可能属脑型和肠型间的中间型;4000拉德组尚未达到脑型损伤的程度。颗粒细胞皱缩,不同于核固缩,具有一定的超微结构特征,并经证明是可以恢复的。在恢复过程中出现核仁,游离多聚核蛋白体显著增多,高尔基复合体十分发达,标志着细胞功能趋于活跃。这表明小鼠小脑颗粒细胞对射线具有很大的抗力。小脑小血管也发生病变,但对颗粒细胞退变坏死似无影响。
In this paper, the histopathological and ultrastructural changes of the cerebellum after a single irradiation of 4000, 8000 and 16000 rads with 60 Co γ ray were studied. Found the most prominent change is the collapse of granular nuclei, necrosis of only a few individual cells. 1600 rad group had obvious symptoms of central nervous system, granulocyte nuclear ruffling rate of 44.95%, certainly a brain-type radiation sickness; 8000 Radar group may be between the brain and intestine type; the Radial group has not yet reached the brain The extent of damage. Granulocyte shrinkage, unlike nuclear pyknosis, has some ultrastructural features that have been shown to be recoverable. In the process of recovery nucleolus appear, free polyribosomes significantly increased, the well-developed Golgi complex, marking the cell function tends to be active. This shows that mouse cerebellar granulosa cells have a great resistance to radiation. Small cerebellar vessels also occur lesions, but no effect on the degeneration and necrosis of granulosa cells.