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目的研究持续性肾脏替代联合血必净对脓毒症患者炎症反应、免疫功能的影响。方法选取2014年3月至2016年2月,在我院接受诊治的脓毒症患者88例。按照治疗方式的不同分为观察组及对照组各44例。对照组患者给予单纯血必净治疗,观察组患者在对照组的基础上加用持续性肾脏替代治疗,对比两组效果。结果治疗后两组的各项免疫指标水平与治疗前对比差异均有统计学意义(均P<0.05);治疗后观察组的CRP、CD3+较对照组含量均明显降低,CD4+明显升高,差异均有统计学意义(均P<0.05)。治疗后两组炎性因子水平与治疗前对比差异均有统计学意义(均P<0.05),治疗后观察组的IL-6、TNF-a以及WBC水平均显著低于对照组,差异均有统计学意义(均P<0.05)。结论持续性肾脏替代联合血必净能有效改善患者炎症反应,增强免疫功能,有利于促进患者早日康复。
Objective To investigate the effect of continuous renal replacement combined with Xuebijing on inflammatory reaction and immune function in sepsis patients. Methods From March 2014 to February 2016, 88 patients with sepsis were treated in our hospital. According to the different treatment methods were divided into observation group and control group of 44 cases. Patients in the control group were treated with pure blood purine. Patients in the observation group were treated with continuous renal replacement therapy on the basis of the control group, and the effects of two groups were compared. Results After treatment, the immunological indexes of the two groups were significantly different from those before treatment (all P <0.05); after treatment, the levels of CRP and CD3 in the observation group were significantly lower than those in the control group, and the levels of CD4 + All were statistically significant (P <0.05). After treatment, the levels of inflammatory cytokines in both groups were significantly different from those before treatment (all P <0.05). After treatment, the levels of IL-6, TNF-a and WBC in the observation group were significantly lower than those in the control group Statistical significance (all P <0.05). Conclusion Continuous renal replacement combined with Xuebijing can effectively improve the patient’s inflammatory response, enhance immune function, help to promote the early recovery of patients.