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近年来用黄连素注射剂引起过敏反应和死亡的病例己有不少报道[中草药遁讯(3):17,1977;天津医药杂志(3):130.1977;中华内科杂志(4):282,1978]。据文献记载:注射黄连素对较大动物有中等程度的毒性,可引起兔呼吸困难、心脏损害、血压降低及不全麻痹(轻瘫),死亡解剖发现肺部出血及充血,亦有发现肾脏受损者。以黄连素0.1g 注射于家兔,即引起呼吸障碍和脱力。临床用药亦证实:黄连素静滴,如剂量过大,可抑制心脏,使血管扩张,血压下降,呼吸抑制[天津医药杂志(5):222,1977]、黄连素100mg 加于10%葡萄糖注射液静漓诱发急性心源性脑缺氧综合征3例,其中2例死亡,1例抢救成功。静滴黄连素之所以能诱发急性心源性脑缺氧综合征,推测系由于增强了乙酰胆碱对心
In recent years, cases of allergic reactions and death caused by injection of berberine have been reported in many cases [Chinese Herbal Medicine (3): 17,1977; Tianjin Medical Journal (3): 130.1977; Chinese Journal of Internal Medicine (4): 282,1978] . According to the literature, injection of berberine has moderate toxicity to larger animals, which can cause respiratory dysfunction, heart damage, hypotension and incomplete paralysis (paralysis) in rabbits. Bleeding and congestion of the lungs are found in the anatomy of death, and kidney receptors Loss of those. Berberine 0.1g injection in rabbits, which cause respiratory disorders and off-force. Clinical medication also confirmed: berberine intravenous, such as the dose is too large, can inhibit the heart, so that vasodilation, blood pressure, respiratory depression [Tianjin Medical Journal (5): 222,1977], berberine 100mg plus 10% glucose injection 3 cases of acute cardio cerebral hypoxemia caused by fluid dripping, of which 2 died, 1 case of rescue success. The reason why intravenous berberine can induce acute cardio-cerebral hypoxemia syndrome, presumably due to increased acetylcholine heart