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缺血再灌注损伤是临床常见且极其重要的问题,包括心肌梗死、卒中、急性肾功能衰竭、肝休克、肠系膜缺血及器官移植后再灌注损伤等各种常见的临床疾病,因此研究缺血再灌注损伤的机制显得尤为重要。现今越来越多的事实证明淋巴细胞参与缺血再灌注损伤,而其中主要是T细胞,因此各种T细胞的亚型被广泛研究,包括NKT细胞、TH17细胞、γδT细胞、CD_4~+T细胞和CD_8~+T细胞等,研究发现γδT细胞在缺血再灌注损伤中发挥着重要的作用。1γδT细胞概述19世纪80年代γδT细胞被定义为一个新型的T细胞,其以多个独特的性质被人们所熟知,无论是解剖分布位置、发育途径、细胞表型、还是抗原识别机制,都与αβT细胞有着显著的区别。γδT细胞作为一种特殊的T细胞亚群,由γ链、δ链和CD3分子共同构成了γδT细胞的抗原识别受体,主要以非
Ischemia-reperfusion injury is a common clinical and extremely important issue, including a variety of common clinical diseases such as myocardial infarction, stroke, acute renal failure, hepatic shock, mesenteric ischemia and reperfusion injury after organ transplantation. Therefore, The mechanism of reperfusion injury is particularly important. Nowadays, more and more facts show that lymphocytes are involved in ischemia-reperfusion injury, but T cells are the main part. Therefore, the subtypes of various T cells are widely studied, including NKT cells, TH17 cells, γδT cells, CD_4 ~ + T Cells and CD_8 ~ + T cells, the study found that γδ T cells play an important role in ischemia-reperfusion injury. 1γδ T Cells Overview γδ T cells were defined as a novel type of T cell in the 1880s that was well known for its unique properties, both in terms of anatomical location, developmental pathways, cell phenotypes, and antigen recognition mechanisms αβ T cells have a significant difference. As a special T cell subsets, γδT cells consist of γ-chain, δ-chain and CD3 molecules, which together constitute the antigen recognition receptor of γδT cells,