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目的 :研究重症胰腺炎患者血小板与内皮细胞的功能。方法 :采用ELISA法和单克隆酶联免疫吸附法测定了 49例急性胰腺炎患者 (其中重症 2 3例 )和 2 4例正常人的血浆内血小板α颗粒膜蛋白、血栓烷B2 、6 酮 前列腺素F1α和血管性假血友病因子水平。结果 :急性胰腺炎患者血浆GMP 14 0、TXB2 、vWF :Ag水平较正常对照组明显升高 ( P <0 0 1) ,6 酮 PGF1α水平明显降低 (P<0 0 5 )。动态观察发现 :轻型胰腺炎患者血浆GMP 14 0、TXB2 、vWF :Ag水平于发病第 5天出现下降趋势 ,而重症患者上述三项指标反而持续升高。结论 :胰腺炎患者血小板处于活化状态 ,内皮细胞功能受损 ,胰腺组织的血液循环障碍与血小板活化、内皮细胞受损有密切关系。
Objective: To study the function of platelets and endothelial cells in patients with severe acute pancreatitis. Methods: The plasma levels of platelet α-granule membrane protein, thromboxane B2, and ketone ketone in 49 patients with severe pancreatitis (23 severe cases) and 24 normal individuals were measured by ELISA and monoclonal antibody-linked immunosorbent assay F1α and von Willebrand factor levels. Results: The levels of plasma GMP 14 0, TXB2 and vWF: Ag in patients with acute pancreatitis were significantly higher than those in normal controls (P <0.01), while the levels of 6 PGF1α were significantly decreased (P <0.05). Dynamic observation found that: the levels of plasma GMP 14 0, TXB2 and vWF: Ag in patients with mild pancreatitis showed a decreasing trend on the 5th day of onset, while those in critically ill patients continued to increase. Conclusion: Platelet is activated in pancreatitis patients, endothelial cell function is impaired, pancreatic blood circulation disorders and platelet activation, endothelial cell damage are closely related.