论文部分内容阅读
[背景]多环芳香烃(PAHs)是已知致癌物质和疑似内分泌干扰物。产前PAHs暴露与儿童早期肥胖相关。[目的]研究儿童和青少年尿液中PAH代谢产物与肥胖结局[体质指数(BMI)的z分数、腰围(WC)和肥胖率]的相关性。[方法]对参加2001—2006年美国国家健康和营养调查的3 189名6~19岁个体进行全样本分析。采用多元线性和logistic回归对BMI z分数、WC、肥胖与单个尿中PAHs化合物浓度和PAHs总和浓度的相关性进行分析。此外,根据发育阶段[即儿童(6~11岁)和青少年(12~19岁)]进行分层分析。[结果]BMI z分数、WC和肥胖与PAHs分子质量之和以及萘代谢产物的总和有正向相关。在6~11岁儿童中,大多数相关性随暴露的四分位数增加而增加,而在青少年中(12~19岁)剂量反应趋势则不太一致。无论是总PAHs还是总萘代谢产物与任何年龄组的超重都不相关,且关于结局与各PAHs之间相关性的证据也很少。[结论]尿中总PAH代谢产物和萘代谢产物与6~11岁儿童中较高的BMI、WC和肥胖相关,在青少年中此相关性呈正向但不太一致。
[Background] Polycyclic aromatic hydrocarbons (PAHs) are known carcinogens and suspected endocrine disruptors. Prenatal PAHs exposure is associated with early childhood obesity. [Objective] To investigate the correlation between PAH metabolites and obesity outcome (z score, waist circumference (WC) and obesity rate of body mass index (BMI)) in children and adolescents. [Methods] A total sample of 3,189 individuals aged 6-19 years who participated in the National Health and Nutrition Examination of the United States from 2001 to 2006 was analyzed. Multivariate linear and logistic regression analysis was used to analyze the association of BMI z scores, WC, obesity with concentrations of PAHs in individual urine and total PAHs concentration. In addition, stratification was based on stages of development [ie, children (6 to 11 years) and adolescents (12 to 19 years)]. [Results] There was a positive correlation between the BMI z score, the sum of molecular weights of WC and obesity and PAHs, and the sum of naphthalene metabolites. The majority of children aged 6 to 11 increased with increasing quartiles of exposure, whereas the trend of dose response in adolescents (12-19 years) was less consistent. Neither total PAHs nor total naphthalene metabolites were associated with overweight in any age group, and there was very little evidence of a correlation between outcome and PAHs. [Conclusion] Total urinary PAH metabolites and naphthalene metabolites are associated with higher BMI, WC, and obesity in children aged 6 to 11 years, with a positive but less consistent correlation in adolescents.