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目的：研究脑梗死急性期患者脑脊液（ＣＳＦ）和血浆中血小板颗粒膜蛋白－１４０（ＧＭＰ－１４０）和血管性假血友病因子（ｖＷＦ）含量的变化及临床意义。方法：应用双抗夹心酶联免疫吸附试验（ＥＬＩＳＡ）法测定了３４例脑梗死急性期病人ＣＳＦ和血浆中ＧＭＰ－１４０、ｖＷＦ的含量。结果：病人组ＣＳＦ和血浆中ＧＭＰ－１４０、ｖＷＦ含量较正常对照组显著升高（Ｐ＜００１）。结论：脑梗死患者急性期存在高凝状态和血小板活化功能亢进以及脑血管内皮的损伤；检测ＣＳＦ中ＧＭＰ－１４０和ｖＷＦ含量的变化对进一步了解急性脑梗死的发病机理和治疗提供了理论依据，对于观察病情演变、判断预后均有重要的临床意义。
Objective: To study the changes and clinical significance of cerebrospinal fluid (CSF) and plasma GMP-140 and vWF in patients with acute cerebral infarction. Methods: The CSF and plasma levels of GMP-140 and vWF in 34 patients with acute cerebral infarction were measured by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results: The levels of CSF and plasma GMP-140 and vWF in patients were significantly higher than those in normal controls (P <001). CONCLUSIONS: There are hypercoagulable states, platelet activation hyperactivity and cerebrovascular endothelium injury in acute stage of cerebral infarction. Detecting the changes of GMP-140 and vWF in CSF provides a theoretical basis for further understanding the pathogenesis and treatment of acute cerebral infarction, For the observation of the evolution of the disease, to determine the prognosis have important clinical significance.