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目的了解浙江台州地区女性宫颈人乳头瘤病毒(HPV)感染率以及基因亚型的分布特征。方法采用液相芯片技术对浙江省台州医院妇科门诊就诊患者的宫颈脱落细胞共6 014例进行HPV基因分型检测,并对该地区女性HPV感染率、基因亚型分布等进行分析。采用SPSS 16.0软件对所得资料进行统计,组间率的比较用χ2检验,P<0.05为差异有统计学意义。结果浙江台州地区女性HPV总感染率为22.15%(1 332/6 014),单一型感染率为16.53%(994/6 014),多重感染率为5.62%(338/6 014)。HPV阳性患者中高危型HPV感染次数占86.01%(1 537/1 787),感染率从高到低依次为HPV52(17.80%)、HPV16(11.86%)、HPV58(10.24%)、HPV56(5.74%)和HPV18(5.54%)。51~60岁组感染率(29.58%)与总感染率(22.15%)比较差异有统计学意义(P<0.05),且不同年龄组女性宫颈HPV感染各亚型分布情况差异有统计学意义。结论浙江省台州地区女性HPV感染率较高,且以高危型HPV52、16、58感染为主,要重视老年妇女的高危型HPV感染。
Objective To investigate the prevalence of cervical HPV infection and the distribution of genotypes in Taizhou, Zhejiang Province. Methods A total of 6 014 cervical exfoliated cells from gynecological clinics of Taizhou Hospital of Zhejiang Province were detected by liquid phase microarray. The genotypes of HPV were detected and the prevalence of HPV infection and the distribution of genotypes were analyzed. SPSS 16.0 software was used to make statistics on the data obtained. The comparisons between groups were compared using χ2 test, P <0.05 was considered statistically significant. Results The total HPV infection rate was 22.15% (1 332/6 014) in Taizhou, Zhejiang Province. The infection rate of single type was 16.53% (994/6 014) and the multiple infection rate was 5.62% (338/6 014). The number of high-risk HPV infection in HPV-positive patients accounted for 86.01% (1 537/1 787), the infection rates were HPV52 (17.80%), HPV16 (11.86%), HPV58 (10.24%), HPV56 ) And HPV18 (5.54%). The infection rate of the group of 51-60 years old (29.58%) was significantly different from the total infection rate (22.15%) (P <0.05), and there were significant differences in the distribution of cervical HPV subtypes in different age groups. Conclusion The prevalence of HPV infection is high in Taizhou, Zhejiang Province. The infection rate of HPV52, HPV58, HPV16, HPV58 is the highest, and the HPV infection of elderly women should be emphasized.